Article
Parkin Somatic Mutations Link Melanoma and Parkinson's Disease.
Journal of genetics and genomics = Yi chuan xue bao - 20 Jun 2016
Levin Lotan, Srour Shani, Gartner Jared, Kapitansky Oxana, Qutob Nouar, Dror Shani, Golan Tamar, Dayan Roy, Brener Ronen, Ziv Tamar, Khaled Mehdi, Schueler-Furman Ora, Samuels Yardena, Levy Carmit
Abstract excerpt
Epidemiological studies suggest a direct link between melanoma and Parkinson's disease (PD); however, the underlying molecular basis is unknown. Since mutations in Parkin are the major driver of early-onset PD and Parkin was recently reported to play a role in cancer development, we hypothesized that Parkin links melanoma and PD. By analyzing whole exome/genome sequencing of Parkin from 246 melanoma patients, we...
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