Cytochrome P450 oxidoreductase genetic polymorphisms A503V and rs2868177 do not significantly affect warfarin stable dosage in Han-Chinese patients with mechanical heart valve replacement.

doi:10.1007/s00228-013-1544-2

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Cytochrome P450 oxidoreductase genetic polymorphisms A503V and rs2868177 do not significantly affect warfarin stable dosage in Han-Chinese patients with mechanical heart valve replacement.

European journal of clinical pharmacology - 1 Oct 2013

Tan Sheng-Lan, Li Zhi, Zhang Wei, Song Guo-Bao, Liu Li-Ming, Peng Juan, Liu Zhao-Qian, Fan Lan, Meng Xiang-Guang, Wang Lian-Sheng, Chen Yao, Zhou Xin-Min, Zhou Hong-Hao

Abstract excerpt

PURPOSE: To investigate the influence of cytochrome P450 oxidoreductase (POR) polymorphisms (A503V and rs2868177) on warfarin stable dosage (WSD) in Han-Chinese patients with mechanical heart valve replacement (MHVR). METHODS: Three hundred and seventeen Han-Chinese MHVR patients on stable maintenance dose of warfarin were enrolled. Blood samples were collected for genotyping analyses of VKORC1 -1639G>A, CYP2C9...

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PMID: 23949431
DOI: 10.1007/s00228-013-1544-2

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VKORC1

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