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Article

Critical residues for cofactor binding and catalytic activity in the aminoglycoside resistance methyltransferase Sgm.

Journal of bacteriology - 1 Sept 2008

Savic Miloje, Ilic-Tomic Tatjana, Macmaster Rachel, Vasiljevic Branka, Conn Graeme L

Abstract excerpt

The 16S rRNA methyltransferase Sgm from "Micromonospora zionensis" confers resistance to aminoglycoside antibiotics by specific modification of the 30S ribosomal A site. Sgm is a member of the FmrO family, distant relatives of the S-adenosyl-L-methionine (SAM)-dependent RNA subfamily of methyltransferase enzymes. Using amino acid conservation across the FmrO family, seven putative key amino acids were selected...

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Share to Aminoglycosides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18586937
DOI: 10.1128/JB.00076-08
PMCID: PMC2519519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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