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Article

Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity.

Nature - 1 Jun 2017

Rego E Hesper, Audette Rebecca E, Rubin Eric J

Abstract excerpt

Microorganisms are often studied as populations but the behaviour of single, individual cells can have important consequences. For example, tuberculosis, caused by the bacterial pathogen Mycobacterium tuberculosis, requires months of antibiotic therapy even though the bulk of the bacterial population dies rapidly. Shorter courses lead to high rates of relapse because subpopulations of bacilli can survive despite...

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PMID: 28569798
DOI: 10.1038/nature22361
PMCID: PMC5567998

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