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Article

Phenotypic bistability in Escherichia coli's central carbon metabolism.

Molecular systems biology - 1 Jul 2014

Kotte Oliver, Volkmer Benjamin, Radzikowski Jakub L, Heinemann Matthias

Abstract excerpt

Fluctuations in intracellular molecule abundance can lead to distinct, coexisting phenotypes in isogenic populations. Although metabolism continuously adapts to unpredictable environmental changes, and although bistability was found in certain substrate-uptake pathways, central carbon metabolism is thought to operate deterministically. Here, we combine experiment and theory to demonstrate that a clonal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24987115
DOI: 10.15252/msb.20135022
PMCID: PMC4299493

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