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Article

Heterogeneity phenotypes in recurrent glioblastoma: a multimodal MRI-based spatial mapping framework for precision treatment.

BMC medical imaging - 26 Sept 2025

Zhu Yan, Huang Dian, Ji Yang, Wang Ranchao, Li Yang, Xu Yuhao, Zhuang Yan, Liu Zhe, Li Yuefeng, Wang Wei

Abstract excerpt

BACKGROUND: To develop a multimodal magnetic resonance imaging (MRI)-based spatial mapping framework for quantitatively characterizing intratumoral heterogeneity in recurrent glioblastoma (rGBM), identifying distinct imaging subregions, and classifying heterogeneity phenotypes predictive of treatment response and survival outcomes. METHODS: A total of 140 rGBM patients were recruited and underwent standardized...

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Identifiers

PMID: 41013339
DOI: 10.1186/s12880-025-01929-1
PMCID: PMC12465940

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