Article
Magnetic resonance perfusion image features uncover an angiogenic subgroup of glioblastoma patients with poor survival and better response to antiangiogenic treatment.
Neuro-oncology - 1 Jul 2017
Liu Tiffany T, Achrol Achal S, Mitchell Lex A, Rodriguez Scott A, Feroze Abdullah, Iv Michael, Kim Christine, Chaudhary Navjot, Gevaert Olivier, Stuart Josh M, Harsh Griffith R, Chang Steven D, Rubin Daniel L
Abstract excerpt
BACKGROUND: In previous clinical trials, antiangiogenic therapies such as bevacizumab did not show efficacy in patients with newly diagnosed glioblastoma (GBM). This may be a result of the heterogeneity of GBM, which has a variety of imaging-based phenotypes and gene expression patterns. In this study, we sought to identify a phenotypic subtype of GBM patients who have distinct tumor-image features and molecular...
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