Article
Identification of noninvasive imaging surrogates for brain tumor gene-expression modules.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2008
Diehn Maximilian, Nardini Christine, Wang David S, McGovern Susan, Jayaraman Mahesh, Liang Yu, Aldape Kenneth, Cha Soonmee, Kuo Michael D
Abstract excerpt
Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults. We combined neuroimaging and DNA microarray analysis to create a multidimensional map of gene-expression patterns in GBM that provided clinically relevant insights into tumor biology. Tumor contrast enhancement and mass effect predicted activation of specific hypoxia and proliferation gene-expression programs, respectively....
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