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Article

Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice.

Physiological genomics - 21 Sept 2005

Zhao Xiaoli, Yoshida Morikatsu, Brotto Leticia, Takeshima Hiroshi, Weisleder Noah, Hirata Yutaka, Nosek Thomas M, Ma Jianjie, Brotto Marco

Abstract excerpt

Sarcalumenin is a Ca2+-binding protein located in the sarcoplasmic reticulum of striated muscle cells, the physiological function of which has not been fully determined yet. Using sarcalumenin knockout (sar(-/-)) mice, we showed that sar ablation altered store-operated Ca2+ entry (SOCE) and enhanced muscle fatigue resistance. Sar(-/-) mice fatigued less with treadmill exercise, and intact isolated soleus and...

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Source

Identifiers

PMID: 15998745
DOI: 10.1152/physiolgenomics.00020.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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