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Article

HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia.

Oncotarget - 25 Apr 2017

Wang Pan, Lan Chuan, Xiong Shuanglong, Zhao Xiuwen, Shan You'an, Hu Rong, Wan Wenwu, Yu Shuangjiang, Liao Bin, Li Guangzhi, Wang Junwei, Zou Dewei, Chen Bing, Feng Hua, Wu Nan

Abstract excerpt

The standard treatment for Glioblastoma multiforme (GBM) is surgical resection and subsequent radiotherapy and chemotherapy. Surgical resection of GBM is typically restricted because of its invasive growth, which results in residual tumor cells including glioma stem cells (GSCs) and differentiated cells. Recurrence has been previously thought to occur as a result of these GSCs, and hypoxic microenvironment...

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Identifiers

PMID: 28427209
DOI: 10.18632/oncotarget.15888
PMCID: PMC5438632

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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