Article
Stemness Marker Detection in the Periphery of Glioblastoma and Ability of Glioblastoma to Generate Glioma Stem Cells: Clinical Correlations.
World neurosurgery - 1 Sept 2017
Raysi Dehcordi Soheila, Ricci Alessandro, Di Vitantonio Hambra, De Paulis Danilo, Luzzi Sabino, Palumbo Paola, Cinque Benedetta, Tempesta Daniela, Coletti Gino, Cipolloni Gianluca, Cifone Maria Grazia, Galzio Renato
Abstract excerpt
BACKGROUND: Recent studies suggested glioma stem cells (GSCs) are key contributors to therapeutic resistance of glioblastoma multiforme (GBM) and are responsible for GBM recurrence. METHODS: We characterized the phenotype of cancer cells in the core and periphery of 20 GBM tumors, correlating clinical outcome to the ability to form GSCs and distinguishing survival based on Ki-67 staining. RESULTS: Similar levels...
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