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Article

Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors

25 May 2009

Abstract excerpt

Glioblastoma multiforme (GBM) remains refractory to conventional therapy. CD133+ GBM cells have been recently isolated and characterized as chemo-/radio-resistant tumor-initiating cells and are hypothesized to be responsible for post-treatment recurrence. In order to explore the molecular properties of tumorigenic CD133+ GBM cells that resist treatment, we isolated CD133+ GBM cells from tumors that are recurrent...

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PMID: 19468690
DOI: 10.1007/s11060-009-9919-z

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