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Article

A missense mutation in damage-specific DNA binding protein 2 is a genetic risk factor for limbal squamous cell carcinoma in horses.

International journal of cancer - 15 Jul 2017

Bellone Rebecca R, Liu Jiayin, Petersen Jessica L, Mack Maura, Singer-Berk Moriel, Drögemüller Cord, Malvick Julia, Wallner Barbara, Brem Gottfried, Penedo M Cecilia, Lassaline Mary

Abstract excerpt

Squamous cell carcinoma (SCC) is the most common cancer of the equine eye, frequently originating at the limbus, with the potential to invade the cornea, cause visual impairment, and result in loss of the eye. Several breeds of horses have a high occurrence of limbal SCC implicating a genetic basis for limbal SCC predisposition. Pedigree analysis in the Haflinger breed supports a simple recessive mode of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28425625
DOI: 10.1002/ijc.30744

Genes

DDB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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