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DDB2 Genetic Risk Factor for Ocular Squamous Cell Carcinoma Identified in Three Additional Horse Breeds.

Genes - 5 Dec 2020

Crausaz Margo, Launois Thomas, Smith-Fleming Kathryn, McCoy Annette M, Knickelbein Kelly E, Bellone Rebecca R

Abstract excerpt

Squamous cell carcinoma (SCC) is the most common cancer affecting the equine eye. A missense variant within the gene damage-specific DNA binding protein 2 (DDB2 c.1013C>T, p.Thr338Met) was previously identified as a causal recessive genetic risk factor for the development of ocular SCC within Haflingers, Belgian Draft horses, and Rocky Mountain Horses, but not in the Appaloosa or Arabian breeds. This study aimed...

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Carcinoma, Squamous Cell
DNA-Binding Proteins
Eye Neoplasms
Gene Frequency
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Proteins

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Identifiers

PMID: 33291392
DOI: 10.3390/genes11121460
PMCID: PMC7762027

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