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Article

SUV39H1 Reduction Is Implicated in Abnormal Inflammation in COPD

20 Apr 2017

Abstract excerpt

Chronic obstructive pulmonary disease(COPD) is characterized by enhanced chronic inflammation in the airways, lung parenchyma, and circulation. We investigated whether SUV39H1, a histone methyltransferase, is causatively implicated in the abnormal inflammation observed in COPD. The SUV39H1 and H3K9me3 levels were reduced in peripheral blood mononuclear cells(PBMCs), primary human small airway epithelial...

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PMID: 28425504
DOI: 10.1038/srep46667

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