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Article

Increased replication capacity following evolution of PYxE insertion in Gag-p6 is associated with enhanced virulence in HIV-1 subtype C from East Africa.

Journal of medical virology - 1 Jan 2017

Aralaguppe Shambhu G, Winner Dane, Singh Kamalendra, Sarafianos Stefan G, Quiñones-Mateu Miguel E, Sönnerborg Anders, Neogi Ujjwal

Abstract excerpt

BACKGROUND: A lower virulence of HIV-1 subtype C (HIV-1C) is suggested to be related to the global dominance of HIV-1C. In this observational study, combining in vivo (clinical monitoring) and in vitro (genotypic, biochemical, and phenotypic assays), we explored whether HIV-1C from East Africa (HIV-1CEA ) is more pathogenic due to the evolution of a PYxE-insertion (CPYxEi ) in the gag-p6 that also could affect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27328744
DOI: 10.1002/jmv.24610

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