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Article

Purification and characterization of naturally occurring HIV-1 (South African subtype C) protease mutants from inclusion bodies.

Protein expression and purification - 1 Jun 2016

Maseko Sibusiso B, Natarajan Satheesh, Sharma Vikas, Bhattacharyya Neelakshi, Govender Thavendran, Sayed Yasien, Maguire Glenn E M, Lin Johnson, Kruger Hendrik G

Abstract excerpt

Human immunodeficiency virus (HIV) infections in sub-Saharan Africa represent about 56% of global infections. Many studies have targeted HIV-1 protease for the development of drugs against AIDS. Recombinant HIV-1 protease is used to screen new drugs from synthetic compounds or natural substances. Along with the wild type (C-SA) we also over-expressed and characterized two mutant forms from patients that had shown...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26917227
DOI: 10.1016/j.pep.2016.02.013

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SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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