Article
Assessment of copy number variation in genes related to drug resistance in Plasmodium vivax and Plasmodium falciparum isolates from the Brazilian Amazon and a systematic review of the literature.
Malaria journal - 19 Apr 2017
Costa Gabriel Luíz, Amaral Lara Cotta, Fontes Cor Jesus Fernandes, Carvalho Luzia Helena, de Brito Cristiana Ferreira Alves, de Sousa Taís Nóbrega
Abstract excerpt
BACKGROUND: Parasite resistance to anti-malarials represents a great obstacle for malaria elimination. The majority of studies have investigated the association between single-nucleotide polymorphisms (SNPs) and drug resistance; however, it is becoming clear that the copy number variation (CNV) is also associated with this parasite phenotype. To provide a baseline for molecular surveillance of anti-malarial drug...
Topics
- Adult
- Brazil
- Drug Resistance
- Female
- Gene Dosage
- Gene Frequency
- Humans
- Male
- Middle Aged
- Plasmodium falciparum
- Plasmodium vivax
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single Nucleotide