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Article

Interferon λ3 gene (IL28B) is associated with spontaneous or treatment-induced viral clearance in hepatitis C virus-infected multitransfused patients with thalassemia.

Transfusion - 1 Jun 2017

Biswas Aritra, Firdaus Rushna, Gupta Debanjali, Ghosh Monika, Saha Kallol, Chowdhury Prosanto, Bhattacharyya Maitreyee, Sadhukhan Provash C

Abstract excerpt

BACKGROUND: Hepatitis C virus (HCV) is the major posttransfusion infection in multitransfused individuals in India with thalassemia major. To our knowledge, this study is the first conducted to correlate and comprehend the effects of the host interleukin (IL)28B gene polymorphism at loci rs12979860 and rs8099917 in spontaneous or interferon (IFN)-induced treatment response in the HCV-seroreactive individuals with...

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PMID: 28419488
DOI: 10.1111/trf.14070

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