Article
IL28B CC-genotype association with HLA-DQB1*0301 allele increases the prediction of spontaneous HCV RNA clearance in thalassaemic HCV-infected patients.
Antiviral therapy - 1 Jan 2011
Mangia Alessandra, Santoro Rosanna, Sarli Roberto, Mottola Leonardo, Piazzolla Valeria, Petruzzellis Daniela, Bacca Donato, Clemente Rocco, Copetti Massimiliano, di Mauro Lazzaro, Lotti Giuseppe, Sacco Michele, Stefano Ippazio
Abstract excerpt
BACKGROUND: A single nucleotide polymorphism (SNP), upstream of the IL28B gene has been recently associated with natural clearance of HCV. In a well-characterized cohort of patients with thalassaemia major exposed to the risk of acquiring HCV infection by blood transfusions, we aimed to replicate this finding and to evaluate whether combining the IL28B genotype and HLA class II alleles allow viral clearance to be...
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