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Article

Characterization of Runx2 phosphorylation sites required for TGF-β1-mediated stimulation of matrix metalloproteinase-13 expression in osteoblastic cells.

Journal of cellular physiology - 1 Feb 2018

Arumugam Balasubramanian, Vairamani Mariappanadar, Partridge Nicola C, Selvamurugan Nagarajan

Abstract excerpt

Transforming growth factor-beta1 (TGF-β1), a highly abundant growth factor in skeletal tissues, stimulates matrix metalloproteinase-13 (MMP-13) expression in osteoblastic cells. MMP-13 plays a critical role in bone remodeling. Runx2, a bone transcription factor, is required for TGF-β1-mediated stimulation of MMP-13 expression in osteoblastic cells. In this study, the molecular mechanism responsible for...

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PMID: 28419442
DOI: 10.1002/jcp.25964

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