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TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation

14 Apr 2015

Abstract excerpt

Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a fundamental role in the regulation of bone organogenesis through the activation of receptor serine/threonine kinases. Perturbations of TGF-β/BMP activity are almost invariably linked to a wide variety of clinical outcomes, i.e., skeletal, extra skeletal anomalies, autoimmune, cancer, and cardiovascular diseases. Phosphorylation of...

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PMID: 26273537
DOI: 10.1038/boneres.2015.5

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