Article
Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3.
Oncotarget - 9 May 2017
Ahn Sung Yong, Yang Ji Hye, Kim Nam Hee, Lee Kyungro, Cha Yong Hoon, Yun Jun Seop, Kang Hee Eun, Lee Yoonmi, Choi Jiwon, Kim Hyun Sil, Yook Jong In
Abstract excerpt
Despite the importance of Ras oncogenes as a therapeutic target in human cancer, their 'undruggable' tertiary structures limit the effectiveness of anti-Ras drugs. Canonical Wnt signaling contributes to Ras activity by glycogen synthase kinase 3 (GSK-3)-dependent phosphorylation at the C-terminus and subsequent degradation. In the accompanying report, we show that the anti-helminthic niclosamide directly binds to...
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