Article
Niclosamide inhibits epithelial-mesenchymal transition and tumor growth in lapatinib-resistant human epidermal growth factor receptor 2-positive breast cancer.
The international journal of biochemistry & cell biology - 1 Feb 2016
Liu Junjun, Chen Xiaosong, Ward Toby, Mao Yan, Bockhorn Jessica, Liu Xiaofei, Wang Gen, Pegram Mark, Shen Kunwei
Abstract excerpt
Acquired resistance to lapatinib, a human epidermal growth factor receptor 2 kinase inhibitor, remains a clinical problem for women with human epidermal growth factor receptor 2-positive advanced breast cancer, as metastasis is commonly observed in these patients. Niclosamide, an anti-helminthic agent, has recently been shown to exhibit cytotoxicity to tumor cells with stem-like characteristics. This study was...
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