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Article

IMU1003, an atrarate derivative, inhibits Wnt/β-catenin signaling.

Biochemical and biophysical research communications - 12 Nov 2020

Yonezawa Honami, Sugawara Aoi, Sakyo Tomoko, Uehara Yoshimasa, Kawano Tomikazu, Nishiya Naoyuki

Abstract excerpt

Aberrant activation of the canonical Wnt/β-catenin signaling pathway triggers tumorigenesis in various tissues. This study identified an atrarate compound, IMU14, derived from filamentous fungi as an inhibitor of Wnt/β-catenin signaling in phenotypic chemical inhibitor screening of the zebrafish eyeless phenotype. Its derivatization resulted in synthesis of IMU1003 with enhanced Wnt inhibitory activity. IMU1003...

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Identifiers

PMID: 32891433
DOI: 10.1016/j.bbrc.2020.08.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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