Article
Repurposing the antihelmintic mebendazole as a hedgehog inhibitor.
Molecular cancer therapeutics - 1 Jan 2015
Larsen Andrew R, Bai Ren-Yuan, Chung Jon H, Borodovsky Alexandra, Rudin Charles M, Riggins Gregory J, Bunz Fred
Abstract excerpt
The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents. Here, we show that mebendazole, a benzamidazole with a long history of safe use against nematode infestations and hydatid disease, potently inhibited Hh signaling and slowed the growth of Hh-driven human medulloblastoma cells at clinically attainable concentrations. As an...
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