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Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study

7 Nov 2022

Abstract excerpt

Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer's disease (AD). We aimed to evaluate the potential causal role of TL in AD endophenotypes (i.e., cognitive performance, N = 2233; brain age and AD-related signatures, N = 1134; and cerebrospinal fluid biomarkers (CSF) of AD and neurodegeneration, N = 304) through a Mendelian...

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Share to Telomeres, Telomerase, and Senescence
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PMID: 36345036
DOI: 10.1186/s13195-022-01101-9

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