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Limitations of the Mycobacterium tuberculosis reference genome H37Rv in the detection of virulence-related loci.

Genomics - 1 Oct 2017

O'Toole Ronan F, Gautam Sanjay S

Abstract excerpt

The genome sequence of Mycobacterium tuberculosis strain H37Rv is an important and valuable reference point in the study of M. tuberculosis phylogeny, molecular epidemiology, and drug-resistance mutations. However, it is becoming apparent that use of H37Rv as a sole reference genome in analysing clinical isolates presents some limitations to fully investigating M. tuberculosis virulence. Here, we examine the...

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PMID: 28743540
DOI: 10.1016/j.ygeno.2017.07.004

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