Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27.

doi:10.18632/oncotarget.16361

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Article

Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27.

Oncotarget - 9 May 2017

Yasuda Kazuyo, Hirohashi Yoshihiko, Mariya Tasuku, Murai Aiko, Tabuchi Yuta, Kuroda Takafumi, Kusumoto Hiroki, Takaya Akari, Yamamoto Eri, Kubo Terufumi, Nakatsugawa Munehide, Kanaseki Takayuki, Tsukahara Tomohide, Tamura Yasuaki, Hirano Hiroshi, Hasegawa Tadashi, Saito Tsuyoshi, Sato Noriyuki, Torigoe Toshihiko

Abstract excerpt

Cancer stem-like cells (CSCs)/ cancer-initiating cells (CICs) are defined by their higher tumor-initiating ability, self-renewal capacity and differentiation capacity. CSCs/CICs are resistant to several therapies including chemotherapy and radiotherapy. CSCs/CICs thus are thought to be responsible for recurrence and distant metastasis, and elucidation of the molecular mechanisms of CSCs/CICs are essential to...

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Identifiers

PMID: 28415561
DOI: 10.18632/oncotarget.16361
PMCID: PMC5458228

Genes

HSF1
CIC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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