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Article

ALDH-1-positive cells exhibited a radioresistant phenotype that was enhanced with hypoxia in cervical cancer.

BMC cancer - 17 Sept 2020

Yao Tingting, Weng Xueling, Yao Yao, Huang Chunxian, Li Jing, Peng Yongpai, Lin Rongchun, Lin Zhongqiu

Abstract excerpt

BACKGROUND: We have previously found there was a small subpopulation of cells with cancer stem cell-like phenotype ALDH-1 in cervical cancer. Radiotherapy has been applied in most of the cervical cancer. However,the mechanisms underlying radioresistance still remained elusive. Our study is to explore whether ALDH+ cell promotes radioresistance by hypoxia. METHODS: Cells were respectively cultured in hypoxia and...

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Identifiers

PMID: 32942996
DOI: 10.1186/s12885-020-07337-8
PMCID: PMC7499852

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