Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer.

Nature cell biology - 1 May 2017

Krebs Angela M, Mitschke Julia, Lasierra Losada María, Schmalhofer Otto, Boerries Melanie, Busch Hauke, Boettcher Martin, Mougiakakos Dimitrios, Reichardt Wilfried, Bronsert Peter, Brunton Valerie G, Pilarsky Christian, Winkler Thomas H, Brabletz Simone, Stemmler Marc P, Brabletz Thomas

Abstract excerpt

Metastasis is the major cause of cancer-associated death. Partial activation of the epithelial-to-mesenchymal transition program (partial EMT) was considered a major driver of tumour progression from initiation to metastasis. However, the role of EMT in promoting metastasis has recently been challenged, in particular concerning effects of the Snail and Twist EMT transcription factors (EMT-TFs) in pancreatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Plasticity
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms, Experimental

Share to Pancreatic Neoplasms

Share to Snail Family Transcription Factors

Share to Tumor Burden

Share to Twist-Related Protein 1

Share to Zinc Finger E-box-Binding Homeobox 1

Source

Identifiers

PMID: 28414315
DOI: 10.1038/ncb3513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer.PMID 28414315Read ↗

ZEB1 in Pancreatic CancerSemantic proximity Read ↗

Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancerSemantic proximity Read ↗

STN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancerSemantic proximity Read ↗

Epithelial and Mesenchymal-like Pancreatic Cancer Cells Exhibit Different Stem Cell Phenotypes Associated with Different Metastatic PropensitiesSemantic proximity Read ↗

Epithelial and Mesenchymal Pancreatic Cancer Cells Exhibit Different Stem Cell Phenotypes Being Associated with Different Metastatic PropensitySemantic proximity Read ↗

Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT.Semantic proximity Read ↗

DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.Semantic proximity Read ↗

BACH1 Promotes Pancreatic Cancer Metastasis by Repressing Epithelial Genes and Enhancing Epithelial–Mesenchymal TransitionSemantic proximity Read ↗

Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMTSemantic proximity Read ↗

Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMTSemantic proximity Read ↗

Dual reporter genetic mouse models of pancreatic cancer identify an epithelial‐to‐mesenchymal transition‐independent metastasis programSemantic proximity Read ↗

Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.