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Article

DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.

Cancer research - 15 Mar 2011

Sureban Sripathi M, May Randal, Lightfoot Stan A, Hoskins Aimee B, Lerner Megan, Brackett Daniel J, Postier Russell G, Ramanujam Rama, Mohammed Altaf, Rao Chinthalapally V, Wyche James H, Anant Shrikant, Houchen Courtney W

Abstract excerpt

Pancreatic cancer is an exceptionally aggressive disease in great need of more effective therapeutic options. Epithelial-mesenchymal transition (EMT) plays a key role in cancer invasion and metastasis, and there is a gain of stem cell properties during EMT. Here we report increased expression of the putative pancreatic stem cell marker DCAMKL-1 in an established KRAS transgenic mouse model of pancreatic cancer...

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Identifiers

PMID: 21285251
DOI: 10.1158/0008-5472.CAN-10-2738
PMCID: PMC3072762

Genes

KRAS
ZEB1
ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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