Article
Elevation of CD16+CD56+ NK-cells and down-regulation of serum interleukin-21 (IL-21) and IL-1α after splenectomy in relapsed hemophagocytic lymphohistiocytosis of unknown cause.
Hematology (Amsterdam, Netherlands) - 1 Sept 2017
Wang Jingshi, Han Wei, Gao Zhuo, Wang Yini, Wu Lin, Zhang Jia, Lai Wenyuan, Wang Zhao
Abstract excerpt
OBJECTIVES: Encouraging progress has been made in application of splenectomy in the treatment of relapsed hemophagocytic lymphohistiocytosis (HLH) of unknown cause. The aim was to determine the roles of lymphocyte subpopulations and inflammatory cytokines in splenectomy. METHODS: We retrospectively analyzed changes in lymphocyte subpopulations and levels of inflammatory cytokines at different time-points before...
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