Article
Brief Report: Genetic Variation of the α1 -Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Aug 2017
McCarthy Cormac, Orr Carl, Fee Laura T, Carroll Tomás P, Dunlea Danielle M, Hunt David J L, Dunne Eimear, O'Connell Paul, McCarthy Geraldine, Kenny Dermot, Fearon Ursula, Veale Douglas J, Reeves Emer P, McElvaney Noel G
Abstract excerpt
OBJECTIVE: To examine the prevalence of α1 -antitrypsin deficiency (AATD) in rheumatoid arthritis (RA), and to determine whether AATD is associated with higher levels of rheumatoid factor (RF), antinuclear antibodies (ANAs), and anti-citrullinated peptide autoantibodies (ACPAs). METHODS: RF, ANAs, and ACPAs were measured by standard immunoturbidimetry, immunofluorescence assay, and enzyme-linked immunosorbent...
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