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Article

High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients.

Experimental & molecular medicine - 14 Apr 2017

Cho Sung-Yup, Park Changho, Na Deukchae, Han Jee Yun, Lee Jieun, Park Ok-Kyoung, Zhang Chengsheng, Sung Chang Ohk, Moon Hyo Eun, Kim Yona, Kim Jeong Hoon, Kim Jong Jae, Khang Shin Kwang, Nam Do-Hyun, Choi Jung Won, Suh Yeon-Lim, Kim Dong Gyu, Park Sung Hye, Youn Hyewon, Yun Kyuson, Kim Jong-Il, Lee Charles, Paek Sun Ha, Park Hansoo

Abstract excerpt

Gliosarcoma (GS) is a rare variant (2%) of glioblastoma (GBM) that poses clinical genomic challenges because of its poor prognosis and limited genomic information. To gain a comprehensive view of the genomic alterations in GS and to understand the molecular etiology of GS, we applied whole-exome sequencing analyses for 28 GS cases (6 blood-matched fresh-frozen tissues for the discovery set, 22 formalin-fixed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28408749
DOI: 10.1038/emm.2017.9
PMCID: PMC5420801

Genes

EGFR
PAK3
PTEN
RASGRF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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