Article
Gliomas: Genetic alterations, mechanisms of metastasis, recurrence, drug resistance, and recent trends in molecular therapeutic options.
Biochemical pharmacology - 1 Jul 2022
Kannan Siddarth, Murugan Avaniyapuram Kannan, Balasubramanian Sathyamoorthy, Munirajan Arasambattu Kannan, Alzahrani Ali S
Abstract excerpt
Glioma is the most common intracranial tumor with poor treatment outcomes and has high morbidity and mortality. Various studies on genomic analyses of glioma found a variety of deregulated genes with somatic mutations including TERT, TP53, IDH1, ATRX, TTN, etc. The genetic alterations in the key genes have been demonstrated to play a crucial role in gliomagenesis by modulating important signaling pathways that...
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