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Article

Novel decay dynamics revealed for virus-mediated drug activation in cytomegalovirus infection.

PLoS pathogens - 1 Apr 2017

Rose Jessica, Emery Vincent C, Kumar Deepali, Asberg Anders, Hartmann Anders, Jardine Alan G, Bignamini Angelo A, Humar Atul, Neumann Avidan U

Abstract excerpt

Human cytomegalovirus (CMV) infection is a substantial cause of morbidity and mortality in immunocompromised hosts and globally is one of the most important congenital infections. The nucleoside analogue ganciclovir (GCV), which requires initial phosphorylation by the viral UL97 kinase, is the mainstay for treatment. To date, CMV decay kinetics during GCV therapy have not been extensively investigated and its...

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Identifiers

PMID: 28406982
DOI: 10.1371/journal.ppat.1006299
PMCID: PMC5391089

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