Article
Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Dec 2013
Schnepf Nathalie, Dhédin Nathalie, Mercier-Delarue Séverine, Andreoli Annalisa, Mamez Anne-Claire, Ferry Christelle, Deback Claire, Ribaud Patricia, Robin Marie, Socié Gérard, Simon François, Mazeron Marie-Christine
Abstract excerpt
We characterised by pyrosequencing, the dynamics of cytomegalovirus populations harbouring mutations A594V in gene UL97 and A834P and Q578H in gene UL54 in a haematopoietic stem cell transplant recipient. Unexpected re-emergence of A594V and decrease of A834P under CMX001 were shown to depend on both the selection pressure exerted by the antiviral treatments and the immune response.
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