Article
The time course of development and impact from viral resistance against ganciclovir in cytomegalovirus infection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Feb 2013
Cunha-Bang C da, Kirkby N, Sønderholm M, Sørensen S S, Sengeløv H, Iversen M, Rasmussen A, Gustafsson F, Frederiksen C M, Kjaer J, Lepri A Cozzi, Lundgren J D
Abstract excerpt
(Val)ganciclovir is used to treat cytomegalovirus (CMV) infection following solid organ (SOT) or hematopoietic stem cell (HSCT) transplantation. Treatment failures occur, but the contribution from 39 known ganciclovir-related mutations (GRMs) in the CMV-UL97 gene remains controversial. We propose a categorization of these GRMs potentially useful when interpreting sequence analyses in clinical settings. The UL97...
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