Article
Characterization of the dynamics of human cytomegalovirus resistance to antiviral drugs by ultra-deep sequencing.
Antiviral research - 1 Jan 2020
Guermouche Hélène, Burrel Sonia, Mercier-Darty Mélanie, Kofman Thomas, Rogier Olivier, Pawlotsky Jean-Michel, Boutolleau David, Rodriguez Christophe
Abstract excerpt
Prophylactic or preemptive treatment strategies are required to prevent human cytomegalovirus (CMV) infections in transplant recipients. However, treatment failure occurs when CMV resistant-associated variants (RAVs) are selected. Although the diversity of CMV is lower than that of RNA viruses, CMV appears to show some genetic instability, with possible minor emerging resistance that may be undetectable by Sanger...
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