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Article

Protein-arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination.

Cancer science - 1 Apr 2017

Funayama Ryo, Taniguchi Hajime, Mizuma Masamichi, Fujishima Fumiyoshi, Kobayashi Minoru, Ohnuma Shinobu, Unno Michiaki, Nakayama Keiko

Abstract excerpt

Expression of the gene for protein-arginine deiminase 2 (PADI2) has been shown to be downregulated in colon cancer, with such downregulation being indicative of a poor prognosis in individuals with this disease. We have now examined the expression of PADI2 in matched colon cancer and normal colon tissue specimens as well as in colon cancer cell lines. We found that isoform 1 of PADI2 is the predominant isoform in...

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Identifiers

PMID: 28403548
DOI: 10.1111/cas.13179
PMCID: PMC5406534

Genes

PADI2

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Protein-arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination.PMID 28403548Read ↗

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