CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice.

doi:10.1038/s41398-023-02453-y

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Article

CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice.

Translational psychiatry - 12 May 2023

Sanchez-Roige Sandra, Jennings Mariela V, Thorpe Hayley H A, Mallari Jazlene E, van der Werf Lieke C, Bianchi Sevim B, Huang Yuye, Lee Calvin, Mallard Travis T, Barnes Samuel A, Wu Jin Yi, Barkley-Levenson Amanda M, Boussaty Ely C, Snethlage Cedric E, Schafer Danielle, Babic Zeljana, Winters Boyer D, Watters Katherine E, Biederer Thomas, Mackillop James, Stephens David N, Elson Sarah L, Fontanillas Pierre, Khokhar Jibran Y, Young Jared W, Palmer Abraham A

Abstract excerpt

Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to act prematurely and is associated with multiple forms of psychopathology, including substance use disorders. We performed genome-wide association studies (GWAS) of eight impulsive personality traits from the Barratt Impulsiveness Scale and the short UPPS-P Impulsive Personality Scale (N = 123,509-133,517 23andMe research...

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