hTERT rs2736098 genetic variants and susceptibility of hepatocellular carcinoma in the Chinese population: a case-control study.

doi:10.1016/s1499-3872(13)60009-0

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hTERT rs2736098 genetic variants and susceptibility of hepatocellular carcinoma in the Chinese population: a case-control study.

Hepatobiliary & pancreatic diseases international : HBPD INT - 1 Feb 2013

Zhang Chao, Tian Ya-Ping, Wang Yue, Guo Feng-Hua, Qin Jun-Fang, Ni Hong

Abstract excerpt

BACKGROUND: The human telomerase reverse transcriptase (hTERT) gene encodes the catalytic subunit of telomerase, which mediates pleiotropic effects, including the regulation of senescence and proliferation and plays an important role in carcinogenesis. This study attempts to clarify the genetic predisposition to hepatocellular carcinoma (HCC), focusing on the hTERT gene rs2736098 polymorphism. METHOD: Four...

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PMID: 23392802
DOI: 10.1016/s1499-3872(13)60009-0

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