Article
Expression of the DYRK1A gene correlates with its 3D positioning in the interphase nucleus of Down syndrome cells.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology - 1 Jun 2015
Paz Nerea, Felipe-Blanco Izaskun, Royo Félix, Zabala Amaia, Guerra-Merino Isabel, García-Orad África, Zugaza José L, Parada Luis A
Abstract excerpt
Down syndrome is a common birth defect caused by trisomy of chromosome 21. Chromosomes occupy distinct territories in interphase nuclei, and their distribution within the nuclear space is nonrandom. In humans with Down syndrome, two chromosomes 21 frequently localize proximal to one another and distant from the third chromosome. Here, we investigated the nuclear organization of DYRK1A and SOD1, two genes mapping...
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