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Article

Evolution and phenotypic characterization of whole HBV genome in compliant patients experiencing unexplained entecavir treatment failure.

Antiviral research - 1 Aug 2021

Marlet Julien, Lier Clément, Roch Emmanuelle, Moreau Alain, Combe Benjamin, Handala Lynda, Lefeuvre Sandrine, Maugey Morgan, Elkrief Laure, d'Alteroche Louis, Potier Pascal, Brand Denys, Gaudy-Graffin Catherine

Abstract excerpt

Entecavir treatment failure can be observed in compliant patients despite an absence of detectable resistance mutations by Pol/RT Sanger sequencing. We hypothesized that these unexplained treatment failures could rely on other mechanisms of viral resistance, especially on mutations selected outside of the Pol/RT domain. Partial virological response to entecavir was observed in three patients treated with...

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Identifiers

PMID: 34214504
DOI: 10.1016/j.antiviral.2021.105106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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