Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen.

doi:10.1016/j.jinf.2013.05.008

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Article

Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen.

The Journal of infection - 1 Oct 2013

Cento Valeria, Van Hemert Formijn, Neumann-Fraune Maria, Mirabelli Carmen, Di Maio Velia-Chiara, Salpini Romina, Bertoli Ada, Micheli Valeria, Gubertini Guido, Romano Sara, Visca Michela, De Sanctis Giuseppe-Maria, Berkhout Ben, Marino Nicoletta, Mazzotta Francesco, Cappiello Giuseppina, Spanò Alberto, Sarrecchia Cesare, Ceccherini-Silberstein Francesca, Andreoni Massimo, Angelico Mario, Verheyen Jens, Perno Carlo Federico, Svicher Valentina

Abstract excerpt

INTRODUCTION: The identification of novel reverse-transcriptase (RT) drug-resistance mutations is critical in predicting the probability of success to anti-HBV treatment. Furthermore, due to HBV-RT/HBsAg gene-overlap, they can have an impact on HBsAg-detection and quantification. METHODS: 356 full-length HBV-RT sequences from 197 drug-naive patients and 159 patients experiencing virological-breakthrough to...

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PMID: 23796863
DOI: 10.1016/j.jinf.2013.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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