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Article

BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis

14 Jan 2016

Abstract excerpt

Objective Blood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. However, the functional impact of BVES loss on tumourigenesis is unknown. Here we define the in vivo role of BVES in colitis-associated cancer (CAC), its cellular function and its relevance to patients with IBD. Design We determined...

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PMID: 28389570
DOI: 10.1136/gutjnl-2015-310255

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