Article
TRIC-B Mutations Causing Osteogenesis Imperfecta.
Biological & pharmaceutical bulletin - 1 Jan 2016
Ichimura Atsuhiko, Takeshima Hiroshi
Abstract excerpt
Trimeric intracellular cation (TRIC) channel subtypes, namely TRIC-A and TRIC-B, are expressed in the endoplasmic/sarcoplasmic reticulum and nuclear envelope, and likely function as monovalent cation channels in various cell types. Our studies using knockout mice so far suggest that TRIC subtypes support Ca2+ release from intracellular stores by mediating counter-cationic fluxes. Several genetic mutations within...
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