Article
TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance.
Cell metabolism - 3 Aug 2011
Yamazaki Daiju, Tabara Yasuharu, Kita Satomi, Hanada Hironori, Komazaki Shinji, Naitou Daisuke, Mishima Aya, Nishi Miyuki, Yamamura Hisao, Yamamoto Shinichiro, Kakizawa Sho, Miyachi Hitoshi, Yamamoto Shintaro, Miyata Toshiyuki, Kawano Yuhei, Kamide Kei, Ogihara Toshio, Hata Akira, Umemura Satoshi, Soma Masayoshi, Takahashi Norio, Imaizumi Yuji, Miki Tetsuro, Iwamoto Takahiro, Takeshima Hiroshi
Abstract excerpt
TRIC channel subtypes, namely TRIC-A and TRIC-B, are intracellular monovalent cation channels postulated to mediate counter-ion movements facilitating physiological Ca(2+) release from internal stores. Tric-a-knockout mice developed hypertension during the daytime due to enhanced myogenic tone in resistance arteries. There are two Ca(2+) release mechanisms in vascular smooth muscle cells (VSMCs); incidental...
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