Article
Layer-by-layer bioassembly of cellularized polylactic acid porous membranes for bone tissue engineering.
Journal of materials science. Materials in medicine - 1 May 2017
Guduric Vera, Metz Carole, Siadous Robin, Bareille Reine, Levato Riccardo, Engel Elisabeth, Fricain Jean-Christophe, Devillard Raphaël, Luzanin Ognjan, Catros Sylvain
Abstract excerpt
The conventional tissue engineering is based on seeding of macroporous scaffold on its surface ("top-down" approach). The main limitation is poor cell viability in the middle of the scaffold due to poor diffusion of oxygen and nutrients and insufficient vascularization. Layer-by-Layer (LBL) bioassembly is based on "bottom-up" approach, which considers assembly of small cellularized blocks. The aim of this work...
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